Structure of PDB 4ivm Chain B

Receptor sequence
>4ivmB (length=464) Species: 9606 (Homo sapiens) [Search protein sequence]
GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNG
AIFELGPGGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYV
GGALHALPTGLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLG
PEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGQ
PDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGL
SLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAIT
AVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP
PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHC
LVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCI
ESGRQAAVSVLGTE
3D structure
PDB4ivm Quantitative structural insight into human variegate porphyria disease.
ChainB
Resolution2.769 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.3.4: protoporphyrinogen oxidase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0048034 heme O biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ivm, PDBe:4ivm, PDBj:4ivm
PDBsum4ivm
PubMed23467411
UniProtP50336|PPOX_HUMAN Protoporphyrinogen oxidase (Gene Name=PPOX)

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