Structure of PDB 4iu7 Chain B

Receptor sequence

>4iu7B (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL

3D structure

PDB

4iu7 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha

Chain

Resolution

2.29 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 Q375 V376 L379 E380 L539 E542	I54 K58 L68 Q71 V72 L75 E76 L227 E230
BS02	1GM	B	L346 A350 E353 L387 M421 I424 G521 L525	L42 A46 E49 L83 M115 I118 G209 L213

External links

PDB	RCSB:4iu7, PDBe:4iu7, PDBj:4iu7
PDBsum	4iu7
PubMed	23524984
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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