Structure of PDB 4itj Chain B

Receptor sequence
>4itjB (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
LNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEH
NEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKA
EMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIAD
LGLASFKMWSKLNNEEHNELTLYYMAPEHLNDVNAKPTEKSDVYSFAVVL
WAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCW
EANPEARPTFPGIEEKFRPFYLSQLE
3D structure
PDB4itj Structural Basis of RIP1 Inhibition by Necrostatins.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D132 K134 E136 N137 D150 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1HX B K45 M67 L70 V75 V76 L78 M92 I154 A155 D156 S161 K39 M61 L64 V69 V70 L72 M86 I148 A149 D150 S155 MOAD: ic50=0.3772uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4itj, PDBe:4itj, PDBj:4itj
PDBsum4itj
PubMed23473668
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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