Structure of PDB 4iti Chain B

Receptor sequence
>4itiB (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
LNVIKMKSSDFLESAEKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEE
AKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLS
VKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFK
MWSKLNNEEHNELGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFAN
KEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEA
RPTFPGIEEKFRPFYLSQLE
3D structure
PDB4iti Structural Basis of RIP1 Inhibition by Necrostatins.
ChainB
Resolution2.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D125 K127 E129 N130 D143 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1HW B A64 M67 N68 V75 V76 L78 L90 M92 H136 D156 S161 F162 W165 A51 M54 N55 V62 V63 L65 L77 M79 H123 D143 S148 F149 W152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4iti, PDBe:4iti, PDBj:4iti
PDBsum4iti
PubMed23473668
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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