Structure of PDB 4ith Chain B

Receptor sequence
>4ithB (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
LNVIKMKSSDFLESAELKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLE
EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPL
SVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF
KMWSKLNNEEHNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFAN
KEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEA
RPTFPGIEEKFRPFYLSQLE
3D structure
PDB4ith Structural Basis of RIP1 Inhibition by Necrostatins.
ChainB
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 D144 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RCM B M67 L70 V75 V76 L78 M92 A155 D156 S161 F162 M55 L58 V63 V64 L66 M80 A143 D144 S149 F150 MOAD: ic50=0.3169uM
BindingDB: IC50=200nM,EC50=18nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ith, PDBe:4ith, PDBj:4ith
PDBsum4ith
PubMed23473668
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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