Structure of PDB 4irr Chain B

Receptor sequence
>4irrB (length=290) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
QQVHLNQDEYKYLKQVEQILREGTRRDDRTGTGTISIFGMQSKYCLRNGT
IPLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIWEKNGDRAFLDN
LGFTSREEGDLGPVYGFQWRHFGAKYVDCHTDYSGQGVDQLAEVIRQIKE
QPDSRRIIMSAWNPSDLGQMVLPPCHTMCQFYVDNGELSCQLYQRSGDMG
LGVPFNLASYGLLTHMIAKVCGLKPGTLVHTLGDAHVYSNHVDALKIQLD
REPYAFPKIRFTRDVASIDDFTSDMIALDDYKCHPKIPMD
3D structure
PDB4irr Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP
ChainB
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E89 W111 Y137 C197 R217 D220
Catalytic site (residue number reindexed from 1) E67 W89 Y115 C175 R195 D198
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B R177 R178 R155 R156
BS02 UMP B R51 C197 Q216 R217 S218 G224 N228 H258 Y260 R29 C175 Q194 R195 S196 G202 N206 H236 Y238
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4irr, PDBe:4irr, PDBj:4irr
PDBsum4irr
PubMed
UniProtQ9Y052

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