Structure of PDB 4iqj Chain B

Receptor sequence
>4iqjB (length=1167) Species: 271 (Thermus aquaticus) [Search protein sequence]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRGYFHLTLLAKDFTGYQNLVRL
ASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRLDLA
EARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVATND
GHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRAMLP
EAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLPEGRTEAQYLRE
LTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELREWT
AEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGSAAG
SLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRVIQY
VRERYGEDKVAQIGTASKAALKDVARVIPHKKAEELAKLIPPKPLQEAEL
RAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVIAAEPLTDLVPLMRD
QEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEARRIVKESKGVELDY
DRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRGLKPRRLEDIIALVS
LYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLRPILDETYGIPVYQE
QIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHRERFVRGAKERGVPE
EEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYVKAHYPVEFMAALLS
VERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFKVVGEEILFGLSAVK
NVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVNKRALESLVKAGALD
AFGDRARLLASLEPLLRWAAETRERGRSGLVGLFAEVEEPPLVEASPLDE
ITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEELSEFVRELPGKPKV
LLSGMVEEVVRKPTGMMARFTLSDETGALEVVVFGRAYEGVSPKLKEDIP
LLVLAEVERVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGVARLKSLLD
EHPGSLPVYLRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDRE
VFLQGNGGGPKEEVVPF
3D structure
PDB4iqj Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K895 V897 G898 M900 K850 V852 G853 M855
BS02 dna B R424 P526 P532 E597 H817 Q928 R395 P491 P492 E552 H772 Q883
BS03 ZN B E72 H95 E68 H83
BS04 ZN B D20 H47 H214 D16 H43 H202
BS05 ZN B H11 H13 E72 D212 H7 H9 E68 D200
BS06 MG B D463 D465 D618 D434 D436 D573
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqj, PDBe:4iqj, PDBj:4iqj
PDBsum4iqj
PubMed23478062
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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