Structure of PDB 4ijn Chain B

Receptor sequence
>4ijnB (length=375) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
VTVLVVNSGSSSLKYAVVRPASGEFLADGIIEEIGSGAVPDHDAALRAAF
DELAAAGLHLEDLDLKAVGHRMVHGGKTFYKPSVVDDELIAKARELSPLA
PLHNPPAIKGIEVARKLLPDLPHIAVFDTAFFHDLPAPASTYAIDRELAE
TWHIKRYGFHGTSHEYVSQQAAIFLDRPLESLNQIVLHLGNGASASAVAG
GKAVDTSMGLTPMEGLVMGTRSGDIDPGVIMYLWRTAGMSVDDIESMLNR
RSGVLGLGGASDFRKLRELIESGDEHAKLAYDVYIHRLRKYIGAYMAVLG
RTDVISFTAGVGENVPPVRRDALAGLGGLGIEIDDALNSAKSDEPRLIST
PDSRVTVLVVPTNEELAIARACVGV
3D structure
PDB4ijn Increasing the structural coverage of tuberculosis drug targets.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N8 R72 H161 R222 E365
Catalytic site (residue number reindexed from 1) N7 R71 H160 R221 E364
Enzyme Commision number 2.7.2.1: acetate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B G191 N192 D263 F264 R265 A310 G311 V312 N315 V316 G190 N191 D262 F263 R264 A309 G310 V311 N314 V315
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0008776 acetate kinase activity
GO:0016301 kinase activity
GO:0016774 phosphotransferase activity, carboxyl group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006083 acetate metabolic process
GO:0006085 acetyl-CoA biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ijn, PDBe:4ijn, PDBj:4ijn
PDBsum4ijn
PubMed25613812
UniProtA0QQK1|ACKA_MYCS2 Acetate kinase (Gene Name=ackA)

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