Structure of PDB 4idv Chain B

Receptor sequence
>4idvB (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
FSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARTEDNEGVLLTEKLKPVD
YEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEE
LMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPED
RALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHML
NGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIH
RVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP
3D structure
PDB4idv Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D515 K517 N520 D534 L551 T559
Catalytic site (residue number reindexed from 1) D175 K177 N180 D194 L211 T219
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 13V B R408 G409 V414 A427 K429 E440 M469 E470 L472 S476 Q479 L522 C533 D534 F535 R68 G69 V74 A87 K89 E100 M129 E130 L132 S136 Q139 L182 C193 D194 F195 BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4idv, PDBe:4idv, PDBj:4idv
PDBsum4idv
PubMed23374866
UniProtQ99558|M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (Gene Name=MAP3K14)

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