Structure of PDB 4ido Chain B

Receptor sequence
>4idoB (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
KAGPVQVLIVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFRKGK
SFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEIF
LINKPDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQ
NVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGAD
GGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNP
NFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFK
AYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKP
FLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESEIDELYI
QYIKHNDSKNIFHAARAAALEH
3D structure
PDB4ido Structural basis for conformational switching and GTP loading of the large G protein atlastin.
ChainB
Resolution2.091 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B R77 K78 G79 K80 S81 F82 W112 R113 G114 R217 D218 P272 V276 R47 K48 G49 K50 S51 F52 W82 R83 G84 R187 D188 P242 V246 PDBbind-CN: -logKd/Ki=4.93,Kd=11.63uM
BS02 ALF B F76 R77 R118 E119 T120 G149 F46 R47 R88 E89 T90 G119
BS03 MG B S81 T120 S51 T90
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4ido, PDBe:4ido, PDBj:4ido
PDBsum4ido
PubMed23334294
UniProtQ8WXF7|ATLA1_HUMAN Atlastin-1 (Gene Name=ATL1)

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