Structure of PDB 4i6g Chain B

Receptor sequence
>4i6gB (length=476) Species: 10090 (Mus musculus) [Search protein sequence]
ASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW
RFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDS
EPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKR
FQALISRMELPKKPAVAVSSQQMESCRAEIQENHDDTYGVPSLEELGFPT
EGLGPAVWQGGETEALARLDKHLENSLLASPTGLSPYLRFGCLSCRLFYY
RLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQ
IPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTR
GDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVG
FGRRTDPSGDYIRRYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYP
RPIVNHAETSRLNIERMKQIYQQLSR
3D structure
PDB4i6g SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q307 W310 W338 H373 W392 W415
Catalytic site (residue number reindexed from 1) Q272 W275 W303 H338 W357 W380
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B S270 Q307 W310 R311 H373 R376 H377 F399 D405 D407 V410 N411 S414 S235 Q272 W275 R276 H338 R341 H342 F364 D370 D372 V375 N376 S379 MOAD: Kd=40uM
External links
PDB RCSB:4i6g, PDBe:4i6g, PDBj:4i6g
PDBsum4i6g
PubMed23503662
UniProtQ9R194|CRY2_MOUSE Cryptochrome-2 (Gene Name=Cry2)

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