Structure of PDB 4i21 Chain B

Receptor sequence
>4i21B (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV
TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWM
IDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTVVDADEYLI
PQ
3D structure
PDB4i21 Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
ChainB
Resolution3.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D837 A839 R841 N842 D855 G874
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153 G172
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y915 E928 G930 E931 R932 P934 Q935 P937 T940 Y944 V948 M952 I953 V980 Y213 E226 G228 E229 R230 P232 Q233 P235 T238 Y242 V246 M250 I251 V278
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4i21, PDBe:4i21, PDBj:4i21
PDBsum4i21
PubMed23273428
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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