Structure of PDB 4hzm Chain B

Receptor sequence
>4hzmB (length=330) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
MGPVMLNVEGCELDAEEREILAHPLVGGLILFTRNYHDPEQLRELVRQIR
AASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFFALHGLEEGGRLAQEA
GWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPAKALAMATRFI
DGMHDAGMKTTGKHFPGHGAVTETPCDPRPETDIRGKDMSVFRTLISENK
LDAIMPAHVIYRAIDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMGSY
AERAQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSR
RELMDSARWKTASAQLNQLHERWQEEKAGH
3D structure
PDB4hzm The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to beta-Lactams.
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1BW B I30 D62 R133 K163 H164 H168 M210 I30 D62 R133 K163 H164 H168 M205 MOAD: Ki=23.2uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0009254 peptidoglycan turnover
GO:0046677 response to antibiotic
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hzm, PDBe:4hzm, PDBj:4hzm
PDBsum4hzm
PubMed24009110
UniProtQ8ZQ06|NAGZ_SALTY Beta-hexosaminidase (Gene Name=nagZ)

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