Structure of PDB 4hy5 Chain B

Receptor sequence
>4hy5B (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
NLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGG
LRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY
3D structure
PDB4hy5 Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic.
ChainB
Resolution1.752 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C300 C303 H320 C327 C44 C47 H64 C71
BS02 1AQ B G306 L307 R308 C309 W310 E311 D314 W323 G50 L51 R52 C53 W54 E55 D58 W67 MOAD: ic50=1.3nM
External links
PDB RCSB:4hy5, PDBe:4hy5, PDBj:4hy5
PDBsum4hy5
PubMed23298277
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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