Structure of PDB 4hy1 Chain B

Receptor sequence
>4hy1B (length=228) Species: 376619 (Francisella tularensis subsp. holarctica LVS) [Search protein sequence]
SIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINIT
LYEDNSIEVADDGRGMPVDIHPEHKMSGIELIMTKLHSGGKFSVGVSVVN
ALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNTGTKIRFWPN
KKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLK
GYLDHKLAETLPAEPSESIKNSYVNLIP
3D structure
PDB4hy1 Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19X B I38 N41 S42 E45 D68 R71 G72 M73 R131 T162 I31 N34 S35 E38 D61 R64 G65 M66 R112 T143 MOAD: Ki=2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hy1, PDBe:4hy1, PDBj:4hy1
PDBsum4hy1
PubMed23352267
UniProtA0A0J9WZF0|PARE_FRATH DNA topoisomerase 4 subunit B (Gene Name=parE)

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