Structure of PDB 4hy0 Chain B

Receptor sequence
>4hy0B (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
TNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHC
GGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLE
3D structure
PDB4hy0 Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic.
ChainB
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C300 C303 H320 C327 C47 C50 H67 C74
BS02 1AQ B K297 K299 G306 L307 T308 D309 W310 E314 Q319 W323 K44 K46 G53 L54 T55 D56 W57 E61 Q66 W70 PDBbind-CN: -logKd/Ki=6.70,IC50=200nM
BindingDB: IC50=200nM
BS03 1AQ B T345 L348 T92 L95 PDBbind-CN: -logKd/Ki=6.70,IC50=200nM
BindingDB: IC50=200nM
External links
PDB RCSB:4hy0, PDBe:4hy0, PDBj:4hy0
PDBsum4hy0
PubMed23298277
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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