Structure of PDB 4hxy Chain B

Receptor sequence

>4hxyB (length=430) Species: 244967 (Streptomyces sp. HK803) [Search protein sequence]

ARTGWFSETWRQLGRAATADRVPGNWLLLGEVPPALGSLFDDPLTAASWD
RSTAPDGVLVGAGAAEDLLAALHEVAGHPTGPVWCVTSRAVGVGTVDDPA
ADVRAAGVWGLGRVAGLELPDRWGGLVDLPERIDDATRRALAGTLTDDGE
DQLAVRDGQLWARRLVTTPAPQTGTWTPKGTVLITGGTGGLGGHVARRVA
EQGSADRILLLSRQGSAAPGATELLEGIRAFGATAEAVAVDVTDRAAMSG
LIDALAAEGAPVRTVVHAAGVVRDVRIAETGAEELAAQMAAKVEGALLLD
ELLPDLDDFVLFSSISGIWGAAGQAGYAAGNACLDALARRRREQGKRAVS
VAWGPWAGGGMLTEHDERELRKRGLTPLLVPAALQAMEQAIMSDRAGDPV
VADVTWSRFLPAFTASRPSPLFGSFEEKAA

3D structure

PDB

4hxy Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene.

Chain

Resolution

1.68 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NDP	B	G191 G194 G195 L196 S217 R218 Q219 D246 V247 A273 A274 G275 A296 K297 S318 Y332 W358 P360 G365 M366 L367	G186 G189 G190 L191 S212 R213 Q214 D241 V242 A268 A269 G270 A291 K292 S313 Y327 W353 P355 G360 M361 L362
BS02	ACA	B	V277 S319 Q329 Y332 M366 L367 D371	V272 S314 Q324 Y327 M361 L362 D366

External links

PDB	RCSB:4hxy, PDBe:4hxy, PDBj:4hxy
PDBsum	4hxy
PubMed	23790488
UniProt	Q6V1M8

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