Structure of PDB 4hw4 Chain B

Receptor sequence
>4hw4B (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
GDELYRQSLEIISRYLREQATGGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKT
INQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB4hw4 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
ChainB
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H224 M231 V253 D256 N260 W261 G262 R263 T266 F318 F319 H44 M51 V73 D76 N80 W81 G82 R83 T86 F138 F139
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4hw4, PDBe:4hw4, PDBj:4hw4
PDBsum4hw4
PubMed23244564
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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