Structure of PDB 4hgt Chain B

Receptor sequence
>4hgtB (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRVGNRYRLGRKIDIYLGTDIAAGEEVAIKLECVQLHIESKIYKMMQGG
VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQM
ISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTH
QHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLP
WQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDD
KPDYSYLRQLFRNLFHRQGFSYDYVFDWNM
3D structure
PDB4hgt Structure-Based Design of Potent and Selective CK1 gamma Inhibitors.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D116 K118
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 15G B E2 R10 E1 R9 BindingDB: IC50=40nM
BS02 15G B R13 I15 I23 A36 K38 P66 M82 L84 L85 L135 I148 D149 R12 I14 I16 A29 K31 P54 M70 L72 L73 L123 I136 D137 BindingDB: IC50=40nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4hgt, PDBe:4hgt, PDBj:4hgt
PDBsum4hgt
PubMed24900428
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

[Back to BioLiP]