Structure of PDB 4hda Chain B

Receptor sequence
>4hdaB (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
TARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQA
QDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQG
RRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICP
ALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAIL
EEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPAT
NRFRFHFQGPCGTTLPEALA
3D structure
PDB4hda A molecular mechanism for direct sirtuin activation by resveratrol.
ChainB
Resolution2.601 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P36 T37 F38 R39 N109 D111 H126
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R71 I142 H158 F223 G224 E225 N226 V254 Y255 R39 I110 H126 F191 G192 E193 N194 V222 Y223
BS02 ZN B C166 C169 C207 C212 C134 C137 C175 C180
BS03 STL B G72 T279 G40 T247
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4hda, PDBe:4hda, PDBj:4hda
PDBsum4hda
PubMed23185430
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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