Structure of PDB 4hd0 Chain B

Receptor sequence
>4hd0B (length=319) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
MKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDL
FHSSRPSPGTLKKAIALLQIPKEHSIPVFAIEGNHDRTQRGPSVLNLLED
FGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAW
FEANKEILKRLFRPTDNAILMLHQGVREFEIGLGDLPEGYLYYARGHIHK
RYETSYSGSPVVYPGSLERWDFGDYEVRYEWDGIKFKERYGVNKGFYIVE
DFKPRFVEIKVRPFIDVKIKEIRKAIKRLIPLIPKNAYVRLNIGWRKPFD
LTEIKELLNVEYLKIDTWR
3D structure
PDB4hd0 Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
ChainB
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D8 H10 D49 H208 D8 H10 D49 H199
BS02 MN B D49 N84 H173 H206 D49 N84 H173 H197
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000729 DNA double-strand break processing
GO:0006302 double-strand break repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4hd0, PDBe:4hd0, PDBj:4hd0
PDBsum4hd0
PubMed23080121
UniProtQ8U1N9|MRE11_PYRFU DNA double-strand break repair protein Mre11 (Gene Name=mre11)

[Back to BioLiP]