Structure of PDB 4hcx Chain B

Receptor sequence
>4hcxB (length=402) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDA
TDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRN
ILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGT
VTLTFTPADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGL
NAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLI
DDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGK
TVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPE
VIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLE
KE
3D structure
PDB4hcx Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis.
ChainB
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D278 D282 D274 D278
BS02 NDP B A77 T78 T80 R85 N99 E309 H312 G313 T314 V315 H318 T330 N331 A73 T74 T76 R81 N95 E305 H308 G309 T310 V311 H314 T326 N327
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hcx, PDBe:4hcx, PDBj:4hcx
PDBsum4hcx
PubMed23409873
UniProtP9WKL1|IDH_MYCTU Isocitrate dehydrogenase [NADP] (Gene Name=icd)

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