Structure of PDB 4h0u Chain B

Receptor sequence
>4h0uB (length=258) Species: 196627 (Corynebacterium glutamicum ATCC 13032) [Search protein sequence]
MTVPTPYEDLLRKIAEEGSHKDGTGTTSLFGQQIRFDLNEGFPLLTTKKV
HFHSVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRS
WPTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLF
QLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFI
WTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSG
YDPHPLIR
3D structure
PDB4h0u Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E61 W83 Y97 C149 R169 D172 P178
Catalytic site (residue number reindexed from 1) E58 W80 Y94 C146 R166 D169 P175
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B R129 R130 R126 R127
BS02 UMP B C149 R169 S170 D172 N180 H210 Y212 C146 R166 S167 D169 N177 H207 Y209
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4h0u, PDBe:4h0u, PDBj:4h0u
PDBsum4h0u
PubMed
UniProtQ8NS38|TYSY_CORGL Thymidylate synthase (Gene Name=thyA)

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