Structure of PDB 4h0n Chain B

Receptor sequence
>4h0nB (length=331) Species: 7108 (Spodoptera frugiperda) [Search protein sequence]
SHKILELYSGIGGMHCAWKESGLDGEIVAAVDINTVANSVYKHNFPETNL
LNRNIQQLTPQVIKKWNVDTILMSPPCQPFTRNGKYLDDNDPRTNSFLYL
IGILDQLDNVDYILMENVKGFENSTVRNLFIDKLKECNFIYQEFLLCPST
VGVPNSRLRYYCTARRNNLTWPFKRRDEIITRLPKDFGVPHSLESIIEED
VDEKFLVPEKMLRCAKVFDICYKTSKRSCCFTKAYTHYADGTGSIFTDKP
REVVQKCYAAAAQNEIGGEKFVELFKELKLRYFTPKEVLMIMCFPKSYNL
PTNISMKQCYRLLGNSVNVKVISELLKILFE
3D structure
PDB4h0n Functional and structural characterization of DNMT2 from Spodoptera frugiperda.
ChainB
Resolution2.712 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C78 E117 R158 R160
Catalytic site (residue number reindexed from 1) C77 E116 R157 R159
Enzyme Commision number 2.1.1.204: tRNA (cytosine(38)-C(5))-methyltransferase.
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y9 S10 G11 I12 G14 D33 I34 N55 I56 S75 P77 Q79 S97 N316 S317 Y8 S9 G10 I11 G13 D32 I33 N54 I55 S74 P76 Q78 S96 N315 S316
BS02 CA B G103 D106 Q107 G102 D105 Q106
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4h0n, PDBe:4h0n, PDBj:4h0n
PDBsum4h0n
PubMed23103599
UniProtA0A2H1VE33|TRDMT_SPOFR tRNA (cytosine(38)-C(5))-methyltransferase (Gene Name=TRDMT1)

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