Structure of PDB 4gty Chain B

Receptor sequence
>4gtyB (length=697) Species: 10090 (Mus musculus) [Search protein sequence]
KSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISK
LKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNAS
FSLKSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIY
KVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSS
EVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYL
NKYLGDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHF
RPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSYCGSGFHGSDNL
FSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGSHGS
LNHLLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTCDPDDDIYHMTVPY
GRPRILLKQHRVCLLQQQQFLTGYSLDLLMPLWASYTFLSNDNCLYQDLR
IPLSPVHKCSYYKLSYGFLTPPRLNHIYSEALLTSNIVPMYQSFQVIWHY
LHDTLLQRYAHERNGINVVSGPVFDFDYDGRYDSLEILKQNSRVIRSQEI
LIPTHFFIVLTSCKQLSETPLECSALESSAYILPHRPDNIESCTHGKRES
SWVEELLTLHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFS
3D structure
PDB4gty Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
ChainB
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP B T238 F239 N259 L272 K277 Y322 Y353 E355 D358 H406 H517 T69 F70 N90 L103 K108 Y153 Y184 E186 D189 H237 H345
BS02 ZN B D200 T238 D405 H406 D31 T69 D236 H237
BS03 ZN B D358 H362 H517 D189 H193 H345
BS04 CA B D780 D782 D784 R786 Y787 D788 D575 D577 D579 R581 Y582 D583
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005044 scavenger receptor activity
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
Biological Process
GO:0006955 immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:4gty, PDBe:4gty, PDBj:4gty
PDBsum4gty
PubMed23027977
UniProtP06802|ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Gene Name=Enpp1);
Q9R1E6|ENPP2_MOUSE Autotaxin (Gene Name=Enpp2)

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