Structure of PDB 4gsy Chain B

Receptor sequence
>4gsyB (length=193) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
SAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIV
LEGDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQG
YARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIDQEDLKFHEK
VIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
3D structure
PDB4gsy Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK).
ChainB
Resolution1.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0Y5 B E37 R48 V51 L52 F66 S69 R70 R92 S96 S97 Y100 Q101 E36 R47 V50 L51 F64 S67 R68 R90 S94 S95 Y98 Q99 MOAD: ic50=120nM
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4gsy, PDBe:4gsy, PDBj:4gsy
PDBsum4gsy
PubMed23043329
UniProtQ6GJI9|KTHY_STAAR Thymidylate kinase (Gene Name=tmk)

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