Structure of PDB 4gs0 Chain B

Receptor sequence
>4gs0B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKN
QLLKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW
PEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYL
SWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV
IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF
IETTKKKL
3D structure
PDB4gs0 Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
ChainB
Resolution1.7961 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D419 C453 R459 T460 Q500
Catalytic site (residue number reindexed from 1) D154 C188 R194 T195 Q235
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y276 K277 N278 C453 S454 A455 I457 G458 R459 Q500 Y17 K18 N19 C188 S189 A190 I192 G193 R194 Q235
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gs0, PDBe:4gs0, PDBj:4gs0
PDBsum4gs0
PubMed23296072
UniProtP29350|PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (Gene Name=PTPN6)

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