Structure of PDB 4gmc Chain B

Receptor sequence
>4gmcB (length=541) Species: 420174 (Hepatitis C virus isolate HC-J4) [Search protein sequence]
SMSYTWTGALITPCAAEMVYATTSRSASLRQKKVTFDRLQVLDDHYRDVL
KEMKAKASTVKAKLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNH
IRSVWEDLLEDTETPIDTTIMAKSEVFCVQGRKPARLIVFPDLGVRVCEK
MALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDTR
CFDSTVTESDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQ
NCGYRRCRASGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVV
ICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSV
AHDASGKRVYYLTRDPTTPLARAAWETARHTPINSWLGNIIMYAPTLWAR
MILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAF
TLHSYSPGEINRVASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCG
RYLFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS
3D structure
PDB4gmc Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase - Acylsulfonamides and acylsulfamides as carboxylic acid replacements
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1BI B A396 H428 L492 G493 V494 P495 R503 A374 H406 L470 G471 V472 P473 R481 PDBbind-CN: -logKd/Ki=7.74,IC50=0.018uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4gmc, PDBe:4gmc, PDBj:4gmc
PDBsum4gmc
PubMed
UniProtO92972|POLG_HCVJ4 Genome polyprotein

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