Structure of PDB 4gfd Chain B

Receptor sequence
>4gfdB (length=193) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
SAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIV
LEGDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQG
YARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIDQEDLKFHEK
VIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
3D structure
PDB4gfd In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0YB B E37 R48 L52 F66 S69 R70 R92 S96 S97 Y100 Q101 E36 R47 L51 F64 S67 R68 R90 S94 S95 Y98 Q99 MOAD: Ki=330pM
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gfd, PDBe:4gfd, PDBj:4gfd
PDBsum4gfd
PubMed22908966
UniProtP65248|KTHY_STAAM Thymidylate kinase (Gene Name=tmk)

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