Structure of PDB 4gdp Chain B

Receptor sequence

>4gdpB (length=502) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

AKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQG
RKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGR
VDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFL
TNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRAAFALNYDSVVQ
RIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQS
VLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCW
SNESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSQTSVTCWSQPL
FFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKC
LDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDD
PVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK
LE

3D structure

PDB

4gdp Mechanistic and Structural Analyses of the Roles of Active Site Residues in Yeast Polyamine Oxidase Fms1: Characterization of the N195A and D94N Enzymes.

Chain

Resolution

1.9998 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H67
Catalytic site (residue number reindexed from 1)	H61
Enzyme Commision number	1.5.3.17: non-specific polyamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G15 G17 A19 E39 A40 R41 G46 R47 G62 A63 S64 W65 H67 V223 V253 P254 G270 W440 A449 Y450 G478 E479 G487 C488 A489 A492	G9 G11 A13 E33 A34 R35 G40 R41 G56 A57 S58 W59 H61 V217 V247 P248 G264 W432 A441 Y442 G470 E471 G479 C480 A481 A484
BS02	PG4	B	W65 H67 W174 Y450 C488	W59 H61 W168 Y442 C480

Gene Ontology

	Molecular Function
GO:0003682	chromatin binding
GO:0016491	oxidoreductase activity
GO:0046592	polyamine oxidase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0052897	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901	spermine oxidase activity
GO:0052903	N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0015940	pantothenate biosynthetic process
GO:0046208	spermine catabolic process

	Cellular Component
GO:0005737	cytoplasm

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4gdp, PDBe:4gdp, PDBj:4gdp
PDBsum	4gdp
PubMed	23034052
UniProt	P50264\|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

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