Structure of PDB 4gbd Chain B

Receptor sequence
>4gbdB (length=434) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
PFDLLLLPTWIVPVEPAGVVLRDHALGIRDGQIALVAPREQAMRHGATEI
RELPGMLLAPGLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVS
EDFIRDGTELAIAEQVKGGITCFSDMYFYPQAICGVVHDSGVRAQVAIPV
LDFPIPGARDSAEAIRQGMALFDDLKHHPRIRIAFGPHAPYTVSDDKLEQ
ILVLTEELDASIQMHVHETAFEVEQAMERNGERPLARLHRLGLLGPRFQA
VHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGFCPVEKLWQAGVNVAI
GTDGAASNNDLDLLGETRTAALLAKAVYGQATALDAHRALRMATLNGARA
LGLERLIGSLEAGKAADLVAFDLSGLAQQPVYDPVSQLIYASGRDCVRHV
WVGGRQLLDDGRLLRHDEQRLIARAREWGAKIAA
3D structure
PDB4gbd Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa.
ChainB
Resolution1.975 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MCF B H74 M77 L89 W92 W98 E101 M132 Y133 F134 H194 H221 E224 H258 D309 H68 M71 L83 W86 W92 E95 M126 Y127 F128 H188 H215 E218 H252 D303 MOAD: Ki=0.0048nM
BS02 ZN B H72 H74 H221 D309 H66 H68 H215 D303
BS03 ZN B E282 N314 D316 E276 N308 D310
BS04 PO4 B G399 D401 G393 D395
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
GO:0090614 5'-methylthioadenosine deaminase activity

View graph for
Molecular Function
External links
PDB RCSB:4gbd, PDBe:4gbd, PDBj:4gbd
PDBsum4gbd
PubMed23050701
UniProtQ9HZ64

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