Structure of PDB 4gah Chain B

Receptor sequence
>4gahB (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
LKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKT
HFLDPKSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPG
FIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQ
LDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLTLEHH
3D structure
PDB4gah Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
ChainB
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.2.2: palmitoyl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0ET B P147 H152 G153 N183 Y184 K185 R186 P187 P98 H103 G104 N134 Y135 K136 R137 P138 MOAD: Ki=0.8uM
PDBbind-CN: -logKd/Ki=6.10,Kd=0.8uM
BS02 0ET B M176 T177 A178 R206 K207 L229 I231 H244 M127 T128 A129 R157 K158 L180 I182 H195 MOAD: Ki=0.8uM
PDBbind-CN: -logKd/Ki=6.10,Kd=0.8uM
BS03 0ET B W86 M169 W44 M120 MOAD: Ki=0.8uM
PDBbind-CN: -logKd/Ki=6.10,Kd=0.8uM
External links
PDB RCSB:4gah, PDBe:4gah, PDBj:4gah
PDBsum4gah
PubMed22871024
UniProtQ5T1C6|THEM4_HUMAN Acyl-coenzyme A thioesterase THEM4 (Gene Name=THEM4)

[Back to BioLiP]