Structure of PDB 4g3e Chain B

Receptor sequence
>4g3eB (length=325) Species: 10090 (Mus musculus) [Search protein sequence]
PVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYRE
EVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACA
GLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYY
LGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDG
LGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHP
WTQGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELR
RKVGKALQEVGGLKSPWKGEYKEPR
3D structure
PDB4g3e The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D517 K519 N522 D536 L553 T561
Catalytic site (residue number reindexed from 1) D170 K172 N175 D189 L206 T214
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0WC B R410 V416 A429 K431 E442 V455 I469 M471 E472 L474 L524 C535 D536 F537 R63 V69 A82 K84 E95 V108 I122 M124 E125 L127 L177 C188 D189 F190
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4g3e, PDBe:4g3e, PDBj:4g3e
PDBsum4g3e
PubMed22921830
UniProtQ9WUL6|M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (Gene Name=Map3k14)

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