Structure of PDB 4g37 Chain B

Receptor sequence
>4g37B (length=539) Species: 7054 (Photinus pyralis) [Search protein sequence]
MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVN
ITYAEYFEMSVRLAEAMKRYGLNTNHRIVVSSENSLQFFMPVLGALFIGV
AVAPANDCYNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQKII
IMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSL
PKGVALPHRALAVRFSHARDPIFGNQIAPDTAILSVVPFHHGFGMFTTLG
YLISGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFLAKSTLIDKY
DLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPK
GDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELSVRGPMIMSGYVNN
PEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGCQVAPAEL
ESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVAS
QVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAK
3D structure
PDB4g37 Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism.
ChainB
Resolution2.396 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S198 R218 H245 T343 E344 K443 Q448 K529
Catalytic site (residue number reindexed from 1) S198 R214 H241 T339 E340 K439 Q444 K525
Enzyme Commision number 1.13.12.7: firefly luciferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLU B H245 F247 T251 G315 G316 A317 P318 G339 Y340 G341 L342 T343 S347 A348 D422 K439 K443 H241 F243 T247 G311 G312 A313 P314 G335 Y336 G337 L338 T339 S343 A344 D418 K435 K439
BS02 XLX B C108 C447 C108 C443
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0004497 monooxygenase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0047077 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0008218 bioluminescence
GO:0046949 fatty-acyl-CoA biosynthetic process
Cellular Component
GO:0005777 peroxisome

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Cellular Component
External links
PDB RCSB:4g37, PDBe:4g37, PDBj:4g37
PDBsum4g37
PubMed22852753
UniProtP08659|LUCI_PHOPY Luciferin 4-monooxygenase

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