Structure of PDB 4g2c Chain B

Receptor sequence

>4g2cB (length=463) Species: 385957 (Amycolatopsis sp. ATCC 39116)

PVDLSTTLSWKSATGEAATMLDELQPNILKAHVRDRLTVLFLGFGDAAEA
RTFLNGLSGLMKSARTHLQEVEAHKLTKAVGTPYLGVGLTAHGYATLGVT
APADPSFTAGAKAAVEKLADPAVTEWEGHYQQTIDAVLLLGDATAGPVRT
LRRQVEALRPASVTVVGEESGLGLANANGDGIEHFGYVDGRSQPLFLTED
VDAERDTTDGVNDWDPSAPLEQVLVPDPAAPDPTVHFGSYFVFRKLEQNV
RLFKEAERDLAHDLGLRGEDRERAGAMLVGRFEDGTPLTAQSAPGSHHPV
GNDFSYDSDKLGQKCPFHAHIRKTNPRGSGGAEAPEEERKHLMARRGQTY
GRRHDDPNADLPPRLRPAKDVGLLFMAFNSNLGNQFEFTQQIWANNPAFP
FPPDGSQPGLDPVIGQGARAPQKYAPEWGHNNVAEATDPIPQAVTMKGGE
YFFMPSLAFLRSL

3D structure

• PDB: 4g2c Identification and characterization of a multifunctional dye peroxidase from a lignin-reactive bacterium.
• Chain: B
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 1.11.1.16: versatile peroxidase.
  1.11.1.19: dye decolorizing peroxidase.
  1.11.1.7: peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	B	V191 D192 G193 R194 S195 Q251 H323 I324 T327 N328 R330 R348 F378 F389 T392 I417	V188 D189 G190 R191 S192 Q248 H320 I321 T324 N325 R327 R345 F375 F386 T389 I414
BS02	MN	B	E260 E286	E257 E283

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0016689 manganese peroxidase activity
• GO:0020037 heme binding
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0052750 reactive-black-5:hydrogen-peroxide oxidoreductase activity
• GO:0140825 lactoperoxidase activity

Biological Process

• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0005576 extracellular region
• GO:0005829 cytosol

External links

• PDB: RCSB:4g2c, PDBe:4g2c, PDBj:4g2c
• PDBsum: 4g2c
• PubMed: 23054399
• UniProt: K7N5M8|DYP2_AMYS7 Multifunctional dye peroxidase DyP2 (Gene Name=dyp2)