Structure of PDB 4fzf Chain B

Receptor sequence
>4fzfB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
MADPEELFTKLERIGKGGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ
QEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDE
FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQ
LTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPP
NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKEL
LKHKFIVKNSKKTSYLTELIDRFKRWKAE
3D structure
PDB4fzf Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism
ChainB
Resolution3.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 A162 D171 T182
Catalytic site (residue number reindexed from 1) D126 K128 A130 N131 A144 D153 T164
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DKI B I30 G31 G33 Y101 L102 D109 L151 F163 I14 G15 G17 Y83 L84 D91 L133 F145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fzf, PDBe:4fzf, PDBj:4fzf
PDBsum4fzf
PubMed23434407
UniProtQ9P289|STK26_HUMAN Serine/threonine-protein kinase 26 (Gene Name=STK26)

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