Structure of PDB 4fzb Chain B

Receptor sequence
>4fzbB (length=188) Species: 10506 (Paramecium bursaria Chlorella virus 1) [Search protein sequence]
TGSAKLISVTKPVVEGVNTAEELIAYAARVSNPENQINNKTASGLLKYCI
RHKHWSIFETAFMTLELKTSRGIAAQVLRHRSFHFQEFSQRYASVQTWWA
TEQEKLYAQSMELYNKALEKGIAKECARFILPLSTPTTIYMSGTIRDWIH
YIELRTSNGTQREHIDLANACKEIFIKEFPSIAKALDW
3D structure
PDB4fzb Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.
ChainB
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B Q85 E86 S88 Q86 E87 S89
BS02 FAD B W54 R78 H79 S81 R173 D174 H177 R182 W55 R79 H80 S82 R146 D147 H150 R155
BS03 0VJ B F87 S88 Q89 R90 E152 F88 S89 Q90 R91 E125
BS04 FAD B H51 H53 S55 R173 H52 H54 S56 R146
BS05 0VJ B A74 Q75 R78 R182 G186 Q188 A75 Q76 R79 R155 G159 Q161
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fzb, PDBe:4fzb, PDBj:4fzb
PDBsum4fzb
PubMed23155486
UniProtO41156|THYX_PBCV1 Probable flavin-dependent thymidylate synthase (Gene Name=A674R)

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