Structure of PDB 4fxd Chain B

Receptor sequence
>4fxdB (length=807) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREG
KTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLL
PYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIK
GADFNSIRNASHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPK
ENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAA
LAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAH
RMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIA
NEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMA
LQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYI
LLHEFSRNGFIVPDKVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTT
VDRNKEDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHK
RVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTR
QLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLEI
DIDNVFKKLLLHAKKKYAALTVNTTVLEVKGLDMKRREFCPLSRDVSIHV
LNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKVITFVIT
KLSVAERAHALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVV
RLSEALG
3D structure
PDB4fxd Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B K1047 G1070 M1131 K1132 K665 G681 M742 K743
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fxd, PDBe:4fxd, PDBj:4fxd
PDBsum4fxd
PubMed23599895
UniProtP13382|DPOLA_YEAST DNA polymerase alpha catalytic subunit A (Gene Name=POL1)

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