Structure of PDB 4fw8 Chain B

Receptor sequence
>4fw8B (length=425) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SFLARQLGPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDL
VGDSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEA
AASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLESTM
RFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGAT
IAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDKIS
EHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTE
GLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGL
AAKGITINAVAPGFIETQMTAIPLATREVGRRLNSLLQGGQPVDVAEAIA
YFASPASNAVTGNVIRVCGQAMIGA
3D structure
PDB4fw8 Crystal structure of hexanoyl-CoA bound to beta-ketoacyl reductase FabG4 of Mycobacterium tuberculosis
ChainB
Resolution2.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S347 Y360 K364
Catalytic site (residue number reindexed from 1) S319 Y332 K336
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI B A222 R223 D244 V245 D267 V268 N295 G297 Y360 K364 P390 A194 R195 D216 V217 D239 V240 N267 G269 Y332 K336 P362
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0030497 fatty acid elongation
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0046459 short-chain fatty acid metabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fw8, PDBe:4fw8, PDBj:4fw8
PDBsum4fw8
PubMed23163771
UniProtO53665

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