Structure of PDB 4fw3 Chain B

Receptor sequence
>4fw3B (length=301) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
NAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVV
EIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSAS
EVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVP
FDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIE
YLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYL
LGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMR
P
3D structure
PDB4fw3 Crystal Structure of the LpxC
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H78 H237 D241 H80 H239 D243
BS02 L52 B E77 H78 T190 F191 I197 G209 S210 H237 D241 H264 E79 H80 T192 F193 I199 G211 S212 H239 D243 H266 BindingDB: Kd=58.6nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0009245 lipid A biosynthetic process
GO:0019637 organophosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fw3, PDBe:4fw3, PDBj:4fw3
PDBsum4fw3
PubMed
UniProtP47205|LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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