Structure of PDB 4ft2 Chain B

Receptor sequence
>4ft2B (length=670) Species: 4577 (Zea mays) [Search protein sequence]
EPEFIGSPVAADEARSNWPKRYLKARCHYRSAKVDNVVYCLGDDVYVKAG
ENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGHKHD
PRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYYDMS
YSVAYSTFANTRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWAVDFN
SFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYVEFVVEKLVGIC
YGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEGHKRK
ILPLPGDVDVICGGPPCQKDEKNKQMVTFMDIVAYLKPKYVLMENVVDIL
KFADGYLGKYALSCLVAMKYQARLGMMVAGCYGLPQFRMRVFLWGALSSM
VLPKYPLPTYDVVVRGGAPNAFSQCMVAYDETQKPSLKKALLLGDAISDL
PKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKDMLDWSFGEGAGPDEGKLL
DHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPEIERVK
LSSGKPLVPDYAMSFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVIIHP
TQARVLTIRENARLQGFPDYYRLFGPIKEKYIQVGNAVAVPVARALGYCL
GQAYLGESEGSDPLYQLPPS
3D structure
PDB4ft2 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C517 E559 R603 R605
Catalytic site (residue number reindexed from 1) C317 E344 R388 R390
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E440 F441 V442 V443 W466 Y469 E477 N481 D484 C485 E240 F241 V242 V243 W266 Y269 E277 N281 D284 C285
BS02 SAH B Y347 G349 D375 F376 P516 Q540 N851 A852 V853 Y170 G172 D198 F199 P316 Q325 N636 A637 V638
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4ft2, PDBe:4ft2, PDBj:4ft2
PDBsum4ft2
PubMed23021223
UniProtQ9AXT8|CMT1_MAIZE DNA (cytosine-5)-methyltransferase 1 (Gene Name=MET2A)

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