Structure of PDB 4fsx Chain B

Receptor sequence
>4fsxB (length=675) Species: 4577 (Zea mays) [Search protein sequence]
HEPEFIGSPVAADEARSNWPKRYGRLKARCHYRSAKVDNVVYCLGDDVYV
KAGENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGH
KHDPRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYY
DMSYSVAYSTFANITRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWA
VDFNSFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYDEFVVEKL
VGICYGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEG
HKRKILPLPGDVDVICGGPPCQGKDEKNKQMVTFMDIVAYLKPKYVLMEN
VVDILKFADGYLGKYALSCLVAMKYQARLGMMVAGCYGLPQFRMRVFLWG
ALSSMVLPKYPLPTYDVVVRGGAPNAFSQCMVAYDETQKPSLKKALLLGD
AISDLPKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKDMLDWSFGEGAGPD
EGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPE
IERVKLSSGKPLVPDYAMSFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQ
VIIHPTQARVLTIRENARLQGFPDYYRLFGPIKEKYIQVGNAVAVPVARA
LGYCLGQAYLGESEGSDPLYQLPPS
3D structure
PDB4fsx Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C517 E559 R603 R605
Catalytic site (residue number reindexed from 1) C321 E349 R393 R395
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y347 S348 G349 G352 M353 D375 F376 N377 K397 A398 N851 A852 Y174 S175 G176 G179 M180 D202 F203 N204 K224 A225 N641 A642
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4fsx, PDBe:4fsx, PDBj:4fsx
PDBsum4fsx
PubMed23021223
UniProtQ9AXT8|CMT1_MAIZE DNA (cytosine-5)-methyltransferase 1 (Gene Name=MET2A)

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