Structure of PDB 4fo4 Chain B

Receptor sequence
>4fo4B (length=346) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSAS
MDTVTEARLAIALAQEGGIGFIHKNMSIEQQAAQVHQVKISGGLRVGAAV
GAAPGNEERVKALVEAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEII
GGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQITAIADA
AGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEV
ILYQGRSYKAYRGMGSLGAMSKLVPEGIEGRIAYKGHLKEIIHQQMGGLR
SCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQITKEAPNYR
3D structure
PDB4fo4 Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP and mycophenolic acid.
ChainB
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP B M51 G304 S305 I306 C307 D340 G342 S364 Y387 G389 M390 G391 E417 M51 G178 S179 I180 C181 D214 G216 S238 Y261 G263 M264 G265 E276
BS02 MOA B S251 S252 N279 G300 T309 M390 S125 S126 N153 G174 T183 M264
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fo4, PDBe:4fo4, PDBj:4fo4
PDBsum4fo4
PubMed
UniProtQ9KTW3

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