Structure of PDB 4fmc Chain B

Receptor sequence
>4fmcB (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
PEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIEL
DGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQW
LQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSA
KNATNVEQSFMTMAAEIKKRM
3D structure
PDB4fmc Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q65
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AF3 B S20 K24 T43 S15 K19 T38
BS02 GDP B G21 G23 K24 S25 C26 Y36 E38 N124 K125 D127 S154 A155 K156 G16 G18 K19 S20 C21 Y31 E33 N119 K120 D122 S149 A150 K151
BS03 MG B S25 T43 D66 S20 T38 D61
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4fmc, PDBe:4fmc, PDBj:4fmc
PDBsum4fmc
PubMed22939626
UniProtP62820|RAB1A_HUMAN Ras-related protein Rab-1A (Gene Name=RAB1A)

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