Structure of PDB 4fj0 Chain B

Receptor sequence
>4fj0B (length=260) Species: 5503 (Curvularia lunata) [Search protein sequence]
YIPGRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVV
SEIKALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFG
HLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFS
VPKHSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSH
HYIPNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNG
KVLTLDGGAA
3D structure
PDB4fj0 Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G29 S153 N154 H164 Y167 K171 Y212
Catalytic site (residue number reindexed from 1) G19 S143 N144 H154 Y157 K161 Y202
Enzyme Commision number 1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G25 R28 I30 A50 N51 S52 I77 N103 S104 G105 L126 T151 Y167 K171 P197 G198 G199 T200 T202 M204 G15 R18 I20 A40 N41 S42 I67 N93 S94 G95 L116 T141 Y157 K161 P187 G188 G189 T190 T192 M194
BS02 HHF B N154 G199 F205 S209 Y212 A228 N144 G189 F195 S199 Y202 A218
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

View graph for
Molecular Function
External links
PDB RCSB:4fj0, PDBe:4fj0, PDBj:4fj0
PDBsum4fj0
PubMed28259640
UniProtO93874

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