Structure of PDB 4fig Chain B

Receptor sequence
>4figB (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
RVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLV
AVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEF
LEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL
LTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD
IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKG
FLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT
3D structure
PDB4fig Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
ChainB
Resolution3.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D143 K145 D147 S148 D161 K170 T181
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B E329 G330 S331 T332 V335 K350 F397 L398 L447 D458 G460 F461 E32 G33 S34 T35 V38 K53 F100 L101 L150 D161 G163 F164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fig, PDBe:4fig, PDBj:4fig
PDBsum4fig
PubMed22988085
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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