Structure of PDB 4fif Chain B

Receptor sequence
>4fifB (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
QRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKL
VAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVME
FLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSI
LLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEV
DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLK
GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR
3D structure
PDB4fif Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D144 K146 D148 S149 D162 K171 T182
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S331 R359 T404 D444 F461 L475 V476 G477 Y480 W481 F516 S35 R63 T108 D148 F165 L179 V180 G181 Y184 W185 F220
BS02 ANP B E329 G330 S331 T332 V335 A348 K350 E366 F397 L398 L447 D458 G460 F461 E33 G34 S35 T36 V39 A52 K54 E70 F101 L102 L151 D162 G164 F165
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fif, PDBe:4fif, PDBj:4fif
PDBsum4fif
PubMed22988085
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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