Structure of PDB 4fie Chain B

Receptor sequence
>4fieB (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
RPKPLVDQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIAT
VRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGD
ELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR
DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR
LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLH
KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR
T
3D structure
PDB4fie Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
ChainB
Resolution3.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D151 K153 D155 S156 D169 K178 T189
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B E329 G330 S331 T332 V335 K350 L398 L447 D458 G460 F461 E40 G41 S42 T43 V46 K61 L109 L158 D169 G171 F172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fie, PDBe:4fie, PDBj:4fie
PDBsum4fie
PubMed22988085
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4)

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