Structure of PDB 4fea Chain B

Receptor sequence
>4feaB (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGF
DVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGV
TPIKDLTAHFRGDRCKTLLEKPKLFFIQACPVEADFLFAYSPGRGSWFVQ
ALCSILEEHGKDLEIMQILTRVNDRVARHFIPCVVSMLTKELYFSQ
3D structure
PDB4fea A class of allosteric caspase inhibitors identified by high-throughput screening.
ChainB
Resolution3.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G29 V30 H88 G89 C130
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0TE B E216 F221 E133 F138 PDBbind-CN: -logKd/Ki=6.47,Ki=0.34uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4fea, PDBe:4fea, PDBj:4fea
PDBsum4fea
PubMed22795132
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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