Structure of PDB 4fe2 Chain B

Receptor sequence
>4fe2B (length=235) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNN
QISSFIFEKLNVAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSF
SKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYL
KEETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRL
WDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK
3D structure
PDB4fe2 Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp.
ChainB
Resolution2.288 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AIR B R93 S99 D174 K176 D196 N197 C198 R199 R214 R93 S99 D174 K176 D196 N197 C198 R199 R214
BS02 ADP B Y7 G9 K10 A11 K12 I14 H68 V83 I85 D191 Y7 G9 K10 A11 K12 I14 H68 V83 I85 D191
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fe2, PDBe:4fe2, PDBj:4fe2
PDBsum4fe2
PubMed24598753
UniProtQ07296|PUR7_STRPN Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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